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Article

On the selection and evolution of regulatory DNA motifs.

Journal of molecular evolution - 1 Oct 2002

Gerland Ulrich, Hwa Terence

Abstract excerpt

The mutation and selection of regulatory DNA sequences are presented as an ideal model system of molecular evolution where genotype, phenotype, and fitness can be explicitly and independently characterized. In this theoretical study, we construct an explicit model for the evolution of regulatory sequences, making use of the known biophysics of the binding of regulatory proteins to DNA sequences, under the...

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PMID: 12355260
DOI: 10.1007/s00239-002-2335-z

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Source receipt: pubmed, retrieved 7 Sept 2026.

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