Selection Shapes Transcriptional Logic and Regulatory Specialization in Genetic Networks.

Abstract excerpt

BACKGROUND: Living organisms need to regulate their gene expression in response to environmental signals and internal cues. This is a computational task where genes act as logic gates that connect to form transcriptional networks, which are shaped at all scales by evolution. Large-scale mutations such as gene duplications and deletions add and remove network components, whereas smaller mutations alter the...

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