Evolution of gene network activity by tuning the strength of negative-feedback regulation.

doi:10.1038/ncomms7226

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Article

Evolution of gene network activity by tuning the strength of negative-feedback regulation.

Nature communications - 11 Feb 2015

Peng Weilin, Liu Ping, Xue Yuan, Acar Murat

Abstract excerpt

Despite the examples of protein evolution via mutations in coding sequences, we have very limited understanding on gene network evolution via changes in cis-regulatory elements. Using the galactose network as a model, here we show how the regulatory promoters of the network contribute to the evolved network activity between two yeast species. In Saccharomyces cerevisiae, we combinatorially replace all regulatory...

Topics

Cloning, Molecular
Evolution, Molecular
Feedback, Physiological
Fungal Proteins
Galactose
Gene Expression Regulation, Fungal
Gene Regulatory Networks
Genes, Fungal
Genes, Switch
Genetic Fitness
Phenotype
Promoter Regions, Genetic
Saccharomyces

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Open in PubMed

Identifiers

PMID: 25670371
DOI: 10.1038/ncomms7226

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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