Article
A machine learning-assisted model for renal urate underexcretion with genetic and clinical variables among Chinese men with gout.
Arthritis research & therapy - 9 Mar 2022
Sun Mingshu, Sun Wenyan, Zhao Xuetong, Li Zhiqiang, Dalbeth Nicola, Ji Aichang, He Yuwei, Qu Hongzhu, Zheng Guangmin, Ma Lidan, Wang Jiayi, Shi Yongyong, Fang Xiangdong, Chen Haibing, Merriman Tony R, Li Changgui
Abstract excerpt
OBJECTIVES: The objective of this study was to develop and validate a prediction model for renal urate underexcretion (RUE) in male gout patients. METHODS: Men with gout enrolled from multicenter cohorts in China were analyzed as the development and validation data sets. The RUE phenotype was defined as fractional excretion of uric acid (FEUA) <5.5%. Candidate genetic and clinical features were screened by the...
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