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Hyperuricemia Subtypes Classified According to Renal Uric Acid Handling Manifesting Distinct Phenotypic and Genetic Profiles in People With Gout.

Arthritis & rheumatology (Hoboken, N.J.) - 1 Jul 2024

Qi Han, Sun Mingshu, Terkeltaub Robert, Merriman Tony R, Chen Haibing, Li Zhiqiang, Ji Aichang, Xue Xiaomei, Sun Wenyan, Wang Can, Li Xinde, He Yuwei, Cui Lingling, Dalbeth Nicola, Li Changgui

Abstract excerpt

OBJECTIVE: Hyperuricemia can be stratified into four subtypes according to renal uric acid handling. The aim of this study was to comprehensively describe the biologic characteristics (including genetic background) of clinically defined hyperuricemia subtypes in two large geographically independent gout cohorts. METHODS: Hyperuricemia subtype was defined as renal uric acid overload (ROL), renal uric acid...

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PMID: 38412854
DOI: 10.1002/art.42838

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