Genome-wide association study of clinically defined gout identifies multiple risk loci and its association with clinical subtypes.

doi:10.1136/annrheumdis-2014-206191

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Article

Genome-wide association study of clinically defined gout identifies multiple risk loci and its association with clinical subtypes.

Annals of the rheumatic diseases - 1 Apr 2016

Matsuo Hirotaka, Yamamoto Ken, Nakaoka Hirofumi, Nakayama Akiyoshi, Sakiyama Masayuki, Chiba Toshinori, Takahashi Atsushi, Nakamura Takahiro, Nakashima Hiroshi, Takada Yuzo, Danjoh Inaho, Shimizu Seiko, Abe Junko, Kawamura Yusuke, Terashige Sho, Ogata Hiraku, Tatsukawa Seishiro, Yin Guang, Okada Rieko, Morita Emi, Naito Mariko, Tokumasu Atsumi, Onoue Hiroyuki, Iwaya Keiichi, Ito Toshimitsu, Takada Tappei, Inoue Katsuhisa, Kato Yukio, Nakamura Yukio, Sakurai Yutaka, Suzuki Hiroshi, Kanai Yoshikatsu, Hosoya Tatsuo, Hamajima Nobuyuki, Inoue Ituro, Kubo Michiaki, Ichida Kimiyoshi, Ooyama Hiroshi, Shimizu Toru, Shinomiya Nariyoshi

Abstract excerpt

OBJECTIVE: Gout, caused by hyperuricaemia, is a multifactorial disease. Although genome-wide association studies (GWASs) of gout have been reported, they included self-reported gout cases in which clinical information was insufficient. Therefore, the relationship between genetic variation and clinical subtypes of gout remains unclear. Here, we first performed a GWAS of clinically defined gout cases only. METHODS:...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 25646370
DOI: 10.1136/annrheumdis-2014-206191
PMCID: PMC4819613

Genes

ABCG2
CUX2
GCKR
MYL2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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