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Deciphering the fibrotic process: mechanism of chronic radiation skin injury fibrosis

15 Feb 2024

Abstract excerpt

This review explores the mechanisms of chronic radiation-induced skin injury fibrosis, focusing on the transition from acute radiation damage to a chronic fibrotic state. It reviewed the cellular and molecular responses of the skin to radiation, highlighting the role of myofibroblasts and the significant impact of Transforming Growth Factor-beta (TGF-β) in promoting fibroblast-to-myofibroblast transformation. The...

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PMID: 38426100
DOI: 10.3389/fimmu.2024.1338922

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