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Article

Aberrant G protein-receptor expression is associated with DNA methylation in aldosterone-producing adenoma.

Molecular and cellular endocrinology - 5 Feb 2018

Itcho Kiyotaka, Oki Kenji, Kobuke Kazuhiro, Yoshii Yoko, Ohno Haruya, Yoneda Masayasu, Hattori Noboru

Abstract excerpt

This study aimed to evaluate the methylation levels of G protein-coupled receptor (GPCR) related genes and the effects of methylation on mRNA expression levels in aldosterone-producing adenoma (APA). DNA methylation array and transcriptome analysis were applied in non-functioning adrenocortical adenoma (NFA) and APA. We investigated 192 GPCR-related genes and found hypo-methylation in the promoter region of 66 of...

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Topics

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Gene Expression Regulation, Neoplastic

Share to Genes, Neoplasm

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Share to Receptors, G-Protein-Coupled

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Source

Identifiers

PMID: 28870781
DOI: 10.1016/j.mce.2017.08.019

Genes

HTR4
PTGER1
GRM3
KCNJ5
TACR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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