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Article

ATP1A1 Mutant in Aldosterone-Producing Adenoma Leads to Cell Proliferation.

International journal of molecular sciences - 12 Oct 2021

Kobuke Kazuhiro, Oki Kenji, Gomez-Sanchez Celso E, Gomez-Sanchez Elise P, Itcho Kiyotaka, Ohno Haruya, Nagano Gaku, Yoshii Yoko, Baba Ryuta, Kodama Takaya, Arihiro Koji, Hattori Noboru, Yoneda Masayasu

Abstract excerpt

The molecular mechanisms by which ATP1A1 mutation-mediated cell proliferation or tumorigenesis in aldosterone-producing adenomas (APAs) have not been elucidated. First, we investigated whether the APA-associated ATP1A1 L104R mutation stimulated cell proliferation. Second, we aimed to clarify the molecular mechanisms by which the ATP1A1 mutation-mediated cell proliferated. We performed transcriptome analysis in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34681640
DOI: 10.3390/ijms222010981
PMCID: PMC8537586

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