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Generation of immunodeficient pig with hereditary tyrosinemia type 1 and their preliminary application for humanized liver

7 Mar 2022

Abstract excerpt

BACKGROUND: Mice with humanized livers are important models to study drug toxicology testing, development of hepatitis virus treatments, and hepatocyte transplantation therapy. However, the huge difference between mouse and human in size and anatomy limited the application of humanized mice in investigating human diseases. Therefore, it is urgent to construct humanized livers in pigs to precisely investigate...

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PMID: 35255981
DOI: 10.1186/s13578-022-00760-3

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