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Article

Integrative genomic analyses identify susceptibility genes underlying COVID-19 hospitalization.

Nature communications - 27 Jul 2021

Pathak Gita A, Singh Kritika, Miller-Fleming Tyne W, Wendt Frank R, Ehsan Nava, Hou Kangcheng, Johnson Ruth, Lu Zeyun, Gopalan Shyamalika, Yengo Loic, Mohammadi Pejman, Pasaniuc Bogdan, Polimanti Renato, Davis Lea K, Mancuso Nicholas

Abstract excerpt

Despite rapid progress in characterizing the role of host genetics in SARS-Cov-2 infection, there is limited understanding of genes and pathways that contribute to COVID-19. Here, we integrate a genome-wide association study of COVID-19 hospitalization (7,885 cases and 961,804 controls from COVID-19 Host Genetics Initiative) with mRNA expression, splicing, and protein levels (n = 18,502). We identify 27 genes...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 34315903
DOI: 10.1038/s41467-021-24824-z
PMCID: PMC8316582

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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