Article
Presence of rare potential pathogenic variants in subjects under 65 years old with very severe or fatal COVID-19.
Scientific reports - 20 Jun 2022
López-Rodríguez Rosario, Del Pozo-Valero Marta, Corton Marta, Minguez Pablo, Ruiz-Hornillos Javier, Pérez-Tomás María Elena, Barreda-Sánchez María, Mancebo Esther, Villaverde Cristina, Núñez-Moreno Gonzalo, Romero Raquel, Paz-Artal Estela, Guillén-Navarro Encarna, Almoguera Berta, Ayuso Carmen
Abstract excerpt
Rare variants affecting host defense against pathogens could be involved in COVID-19 severity and may help explain fatal outcomes in young and middle-aged patients. Our aim was to report the presence of rare genetic variants in certain genes, by using whole exome sequencing, in a selected group of COVID-19 patients under 65 years who required intubation or resulting in death (n = 44). To this end, different...
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