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Article

Intertumor and intratumor heterogeneity of PIK3CA mutations in extramammary Paget's disease.

The Journal of dermatology - 1 May 2022

Kusaba Yudo, Kajihara Ikko, Myangat Tselmeg Mijiddorj, Tanaka Kenichiro, Sakamoto Ryoko, Maeda-Otsuka Saki, Yamada-Kanazawa Saori, Sawamura Soichiro, Kanemaru Hisashi, Nishimura Yuki, Nakamura-Kashiwada Kayo, Makino Katsunari, Miyashita Azusa, Aoi Jun, Masuguchi Shinichi, Fukushima Satoshi

Abstract excerpt

Although the prognosis of patients with extramammary Paget's disease (EMPD) treated with radical resection is good, the prognosis of EMPD with distant metastasis is very poor. PIK3CA mutations predict a good response to PIK3CA inhibitors. The aim of this study was to investigate the occurrence rate of PIK3CA mutations (including multiple mutations [MM]) related to the intertumor and intratumor heterogeneity in...

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Identifiers

PMID: 35253277
DOI: 10.1111/1346-8138.16343

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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