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Article

Genetic dissection of intratumor heterogeneity of PD-L1 expression in EGFR-mutated lung adenocarcinoma.

Thoracic cancer - 1 Aug 2023

Kunimasa Kei, Hirotsu Yosuke, Amemiya Kenji, Honma Keiichiro, Nakamura Harumi, Nishino Kazumi, Omata Masao

Abstract excerpt

In this study, we investigated the association between PD-L1 expression in tumor cells and underlying genetic mutations, which was analyzed in detail using laser microdissection and next-generation sequencing analysis. To investigate whether driver mutations are involved in the background of PD-L1 expression, the EGFR major activating mutation was selected as the most frequent driver mutation. Surgical resection...

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Identifiers

PMID: 37442887
DOI: 10.1111/1759-7714.15038
PMCID: PMC10396783

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