Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Correlation of DLC1 gene methylation with oncogenic PIK3CA mutations in extramammary Paget's disease.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Aug 2012

Kang Zhihua, Xu Feng, Zhang Qiao-An, Lin Jinran, Wu Zhiyuan, Zhang Xinju, Luo Yan, Xu Jinhua, Guan Ming

Abstract excerpt

Extramammary Paget's disease is a rare cutaneous malignant neoplasm. The genetic and epigenetic mechanisms underlying its pathology remain unknown. In this study, we investigated the expression levels, and mutation and methylation status of a common tumor suppressor gene, deleted in liver cancer 1 (DLC1), and an oncogene, PIK3CA, in tumor (n=132) and normal tissues (n=20) from unrelated patients. The presence of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Class I Phosphatidylinositol 3-Kinases
Share to Down-Regulation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Silencing

Share to GTPase-Activating Proteins

Share to Phosphatidylinositol 3-Kinases

Share to Skin Neoplasms

Share to Tumor Suppressor Proteins

Source

Identifiers

PMID: 22522847
DOI: 10.1038/modpathol.2012.65

Genes

DLC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 10 closest

Correlation of DLC1 gene methylation with oncogenic PIK3CA mutations in extramammary Paget's disease.PMID 22522847Read ↗

Oncogenic mutations in extramammary Paget's disease and their clinical relevance.Semantic proximity Read ↗

Intertumor and intratumor heterogeneity of PIK3CA mutations in extramammary Paget's disease.Semantic proximity Read ↗

Association of genetic alterations with prognosis in extramammary Paget disease: insights into the involvement of somatic CDKN2A variants in patients with a poor prognosis.Semantic proximity Read ↗

Downregulation of DLC-1 gene by promoter methylation during primary colorectal cancer progression.Semantic proximity Read ↗

Promoter hypermethylation of CDKN2A, MGMT, MLH1, and DAPK genes in laryngeal squamous cell carcinoma and their associations with clinical profiles of the patientsSemantic proximity Read ↗

Genetic Analysis of Mismatch Repair Genes Alterations in Extramammary Paget DiseaseSemantic proximity Read ↗

p16/INK4a gene methylation is a frequent finding in pulmonary MALT lymphomas at diagnosis.Semantic proximity Read ↗

Epigenetic Down-Regulation of <i>CDKN1C/p57KIP2</i> in Pancreatic Ductal Neoplasms Identified by Gene Expression ProfilingSemantic proximity Read ↗

Promoter hypermethylation along with LOH, but not mutation, contributes to inactivation of DLC-1 in nasopharyngeal carcinoma.Semantic proximity Read ↗

Genetic and epigenetic alterations of DLC-1, a candidate tumor suppressor gene, in nasopharyngeal carcinoma.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.