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Article

Circulating GDF-15: a biomarker for metabolic dysregulation and aging in people living with HIV

4 Jun 2024

Abstract excerpt

Despite effective control of HIV replication by antiretroviral therapy (ART), a significant number of people living with HIV (PLWH) fail to achieve complete immune reconstitution and thus are deemed immune non-responders (INRs). Compared with immune responders (IRs) who have restored their CD4 T cell numbers and functions, CD4 T cells from these INRs exhibit prominent mitochondrial dysfunction and premature...

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PMID: 38895099
DOI: 10.3389/fragi.2024.1414866

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