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Article

Role of Ion Distribution and Energy Barriers for Concerted Motion of Subunits in Selectivity Filter Gating of a K+ Channel.

Journal of molecular biology - 15 May 2022

Rauh Oliver, Opper Jennifer, Sturm Maximilian, Drexler Nils, Scheub Deborah D, Hansen Ulf-P, Thiel Gerhard, Schroeder Indra

Abstract excerpt

Most potassium channels have two main gate locations, hosting an inner gate at the cytosolic entrance and a filter gate in the selectivity filter; the function of these gates is in many channels coupled. To obtain exclusive insights into the molecular mechanisms that determine opening and closing of the filter gate, we use a combination of single-channel recordings and gating analysis in the minimal viral channel...

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Identifiers

PMID: 35248543
DOI: 10.1016/j.jmb.2022.167522

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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