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Article

Mutations reveal voltage gating of CNGA1 channels in saturating cGMP.

The Journal of general physiology - 1 Aug 2009

Martínez-François Juan Ramón, Xu Yanping, Lu Zhe

Abstract excerpt

Activity of cyclic nucleotide-gated (CNG) cation channels underlies signal transduction in vertebrate visual receptors. These highly specialized receptor channels open when they bind cyclic GMP (cGMP). Here, we find that certain mutations restricted to the region around the ion selectivity filter...

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Share to Cyclic GMP
Share to Cyclic Nucleotide-Gated Cation Channels
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Ion Channel Gating

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Share to Potassium Channels, Voltage-Gated

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Source

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Identifiers

PMID: 19635856
DOI: 10.1085/jgp.200910240
PMCID: PMC2717697

Genes

CNGA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19635856-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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