Article

Somatic structural variation targets neurodevelopmental genes and identifies <i>SHANK2</i> as a tumor suppressor in neuroblastoma

2019-03-09

Abstract excerpt

<h4>ABSTRACT</h4> Neuroblastoma is a malignancy of the developing sympathetic nervous system that accounts for 12% of childhood cancer deaths. Like many childhood cancers, neuroblastoma exhibits a relative paucity of somatic single nucleotide variants (SNVs) and small insertions and deletions (indels) compared to adult cancers. Here, we assessed the contribution of somatic structural variation (SV) in neuroblasto...

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Literature Corpus work: 1da2fc91-e47e-572a-bf99-07d7a56ae2e5
DOI: 10.1101/572248

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