Article

ILF3 safeguards telomeres from aberrant homologous recombination as a telomeric R-loop reader

2023-11-22

Abstract excerpt

Abstract Telomeres are specialized structures at the ends of linear chromosomes that protect genome stability. The telomeric repeat-containing RNA (TERRA) that is transcribed from subtelomeric regions can invade into double-stranded DNA regions and form RNA:DNA hybrid-containing structure called R-loop. In tumor cells, R-loop formation is closely linked to gene expression and the alternative lengthening of telomer...

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Literature Corpus work: 95093003-e00d-5111-b63f-410c07527223
DOI: 10.1093/procel/pwad054

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