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The role of testosterone in chronic kidney disease and kidney function in men and women: a bi-directional Mendelian randomization study in the UK Biobank.

BMC medicine - 4 Jun 2020

Zhao Jie V, Schooling C Mary

Abstract excerpt

BACKGROUND: Chronic kidney disease (CKD) has an apparent sex disparity, with a more rapid progress in men than in women. Whether the well-established sex-specific evolutionary biology trade-off between reproduction and longevity might inform CKD has not previously been considered. Relevant evidence from randomized controlled trials (RCTs) is not available. METHODS: We used a bi-directional Mendelian randomization...

Topics

Biological Specimen Banks
Female
Humans
Male
Mendelian Randomization Analysis
Polymorphism, Single Nucleotide
Renal Insufficiency, Chronic
Testosterone
United Kingdom

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PMID: 32493397
DOI: 10.1186/s12916-020-01594-x
PMCID: PMC7271464

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