Sex-specific Associations of Sex Hormone Binding Globulin with CKD and Kidney Function: A Univariable and Multivariable Mendelian Randomization Study in the UK Biobank.

doi:10.1681/ASN.2020050659

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Article

Sex-specific Associations of Sex Hormone Binding Globulin with CKD and Kidney Function: A Univariable and Multivariable Mendelian Randomization Study in the UK Biobank.

Journal of the American Society of Nephrology : JASN - 1 Mar 2021

Zhao Jie V, Schooling C Mary

Abstract excerpt

BACKGROUND: Kidney function declines faster in men. Testosterone levels may mediate the sex disparity. Correspondingly, levels of sex hormone binding globulin (SHBG), which modulates sex hormones, might also be relevant to the lower kidney function in men. The sex-specific role of SHBG is unclear. METHODS: A sex-specific, Mendelian randomization (MR) study provided unconfounded estimates of SHBG levels among the...

Topics

Albuminuria
Biological Specimen Banks
Female
Genome-Wide Association Study
Glomerular Filtration Rate
Humans
Male
Mendelian Randomization Analysis
Multivariate Analysis
Polymorphism, Single Nucleotide

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Renal Insufficiency, Chronic

Risk Factors

Sex Factors

Sex Hormone-Binding Globulin

Testosterone

United Kingdom

Source

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Identifiers

PMID: 33318152
DOI: 10.1681/ASN.2020050659
PMCID: PMC7920164

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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