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Article

Impact of sex hormone-binding globulin on the human phenome.

Human molecular genetics - 21 Jul 2020

Arathimos Ryan, Millard Louise A C, Bell Joshua A, Relton Caroline L, Suderman Matthew

Abstract excerpt

BACKGROUND: Sex hormone-binding globulin (SHBG) is a circulating glycoprotein and a regulator of sex hormone levels, which has been shown to influence various traits and diseases. The molecular nature of SHBG makes it a feasible target for preventative or therapeutic interventions. A systematic study of its effects across the human phenome may uncover novel associations. METHODS: We used a Mendelian randomization...

Topics

Carrier Proteins
Female
Genetic Predisposition to Disease
Genome-Wide Association Study
Gonadal Steroid Hormones
Humans
Male
Mendelian Randomization Analysis
Middle Aged
Phenomics
Phenotype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymorphism, Single Nucleotide

Sex Hormone-Binding Globulin

Source

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Identifiers

PMID: 32533189
DOI: 10.1093/hmg/ddz269
PMCID: PMC7372548

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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