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Article

Effects of PNPLA3 on liver fat and metabolic profile in Hispanic children and adolescents.

Diabetes - 1 Dec 2010

Goran Michael I, Walker Ryan, Le Kim-Anne, Mahurkar Swapna, Vikman Susanna, Davis Jaimie N, Spruijt-Metz Donna, Weigensberg Marc J, Allayee Hooman

Abstract excerpt

OBJECTIVE: A genome-wide study of adults identified a variant of PNPLA3 (rs738409) associated with ∼twofold higher liver fat. The purpose of this study was to examine the influence of PNPLA3 genotype on liver fat and other related metabolic outcomes in obese Hispanic children and adolescents. RESEARCH DESIGN AND METHODS: Three hundred and twenty-seven Hispanics aged 8-18 years were genotyped for rs738409. One...

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Source

Open in PubMed Open full text

Identifiers

PMID: 20852027
DOI: 10.2337/db10-0554
PMCID: PMC2992774

Genes

PNPLA3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Effects of PNPLA3 on liver fat and metabolic profile in Hispanic children and adolescents.PMID 20852027Read ↗

Increased hepatic fat in overweight Hispanic youth influenced by interaction between genetic variation in PNPLA3 and high dietary carbohydrate and sugar consumption.Semantic proximity Read ↗

A common variant in the patatin-like phospholipase 3 gene (PNPLA3) is associated with fatty liver disease in obese children and adolescents.Semantic proximity Read ↗

Genetic and clinical markers of elevated liver fat content in overweight and obese Hispanic children.Semantic proximity Read ↗

Genetic Risk for Hepatic Fat among an Ethnically Diverse Cohort of Youth: The Exploring Perinatal Outcomes among Children Study.Semantic proximity Read ↗

Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease.Semantic proximity Read ↗

PNPLA3 Genotype, Arachidonic Acid Intake, and Unsaturated Fat Intake Influences Liver Fibrosis in Hispanic Youth with Obesity.Semantic proximity Read ↗

A common variant in PNPLA3, which encodes adiponutrin, is associated with liver fat content in humans.Semantic proximity Read ↗

Association of PNPLA3 with non-alcoholic fatty liver disease in a minority cohort: the Insulin Resistance Atherosclerosis Family Study.Semantic proximity Read ↗

The Expression of PNPLA3 Polymorphism could be the Key for Severe Liver Disease in NAFLD in Hispanic Population.Semantic proximity Read ↗

Hepatic fat accumulation is modulated by the interaction between the rs738409 variant in the PNPLA3 gene and the dietary omega6/omega3 PUFA intake.Semantic proximity Read ↗

Metabolic Features of Nonalcoholic Fatty Liver (NAFL) in Obese Adolescents: Findings From a Multiethnic Cohort.Semantic proximity Read ↗

The association between hepatic fat content and liver injury in obese children and adolescents: effects of ethnicity, insulin resistance, and common gene variants.Semantic proximity Read ↗

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