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Digital Nucleic Acid Signal Amplification Platform for Highly Sensitive DNA Mutation Analysis.

Analytical chemistry - 8 Mar 2022

Wu Haiping, Ma Xueping, Chu Yanan, Qi Xiemin, Zou Bingjie, Liu Yunlong, Zhou Guohua

Abstract excerpt

Digital nucleic acid analysis technology has shown great application potential due to its excellent performance. However, most current digital nucleic acid detection methods are based on PCR or other template amplification strategies. Here, we present an alternative analysis platform based on digital nucleic acid signal amplification in droplets termed dNASA. Using a bead-based controllable extension bridged...

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PMID: 35212518
DOI: 10.1021/acs.analchem.1c04765

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