Programmable AND-gate strategy to reduce false positives in rolling circle amplification.

Abstract excerpt

Improving the specificity of biosensors by reducing their false positive rate is a long-standing challenge, particularly for point-of-care (POC) diagnostics. An emerging and potentially impactful class of POC biosensor is those that can detect specific nucleic acid sequences. These sensors often use isothermal amplification of nucleic acid sequences, which is considered suitable for POC use due to its relative...

Topics

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• Biosensing Techniques
• DNA
• Equipment Design
• False Positive Reactions
• Nucleic Acid Amplification Techniques