Article
Maximal Information Coefficient-Based Testing to Identify Epistasis in Case-Control Association Studies.
Computational and mathematical methods in medicine - 1 Jan 2022
Guo Yingjie, Yuan Zhian, Liang Zhen, Wang Yang, Wang Yanpeng, Xu Lei
Abstract excerpt
Interactions between genetic variants (epistasis) are ubiquitous in the model system and can significantly affect evolutionary adaptation, genetic mapping, and precision medical efforts. In this paper, we proposed a method for epistasis detection, called EpiMIC (epistasis detection through a maximal information coefficient (MIC)). MIC is a promising bivariate dependence measure explicitly designed for rapidly...
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