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Article

Sex-specific differences in KCC2 localisation and inhibitory synaptic transmission in the rat hippocampus.

Scientific reports - 24 Feb 2022

Wolf Daniele C, Sanon Nathalie T, Cunha Alexandra O S, Chen Jia-Shu, Shaker Tarek, Elhassan Abdul-Rahman, do Nascimento Antônia Sâmia Fernandes, Di Cristo Graziella, Weil Alexander G

Abstract excerpt

Sexual differentiation of the brain is influenced by testosterone and its metabolites during the perinatal period, when many aspects of brain development, including the maturation of GABAergic transmission, occur. Whether and how testosterone signaling during the perinatal period affects GABAergic transmission is unclear. Here, we analyzed GABAergic circuit functional markers in male, female, testosterone-treated...

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Identifiers

PMID: 35210456
DOI: 10.1038/s41598-022-06769-5
PMCID: PMC8873453

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