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Article

Sexual Differentiation of the Brain Requires Perinatal Kisspeptin-GnRH Neuron Signaling

12 Nov 2014

Abstract excerpt

Sex differences in brain function underlie robust differences between males and females in both normal and disease states. Although alternative mechanisms exist, sexual differentiation of the male mammalian brain is initiated predominantly by testosterone secreted by the testes during the perinatal period. Despite considerable advances in understanding how testosterone and its metabolite estradiol sexually...

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PMID: 25392497
DOI: 10.1523/jneurosci.3061-14.2014

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