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Article

Stage-differentiated ensemble modeling of DNA methylation landscapes uncovers salient biomarkers and prognostic signatures in colorectal cancer progression.

PloS one - 1 Jan 2022

Muthamilselvan Sangeetha, Raghavendran Abirami, Palaniappan Ashok

Abstract excerpt

BACKGROUND: Aberrant DNA methylation acts epigenetically to skew the gene transcription rate up or down, contributing to cancer etiology. A gap in our understanding concerns the epigenomics of stagewise cancer progression. In this study, we have developed a comprehensive computational framework for the stage-differentiated modelling of DNA methylation landscapes in colorectal cancer (CRC). METHODS: The...

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Identifiers

PMID: 35202405
DOI: 10.1371/journal.pone.0249151
PMCID: PMC8870460

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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