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Article

The LIGHT switch: mechanisms of fibroblast pathology in eosinophilic esophagitis

1 Feb 2022

Abstract excerpt

New work from Manresa et al. defines LIGHT (TNFSF14)-driven signaling pathways that push fibroblasts to become pathogenic in eosinophilic esophagitis (EoE) 1 . The authors report that fibroblasts switch away from homeostatic WNT signaling towards a dominant pathway of pro-inflammatory non-canonical lymphotoxin beta receptor (LTβR) signaling. These findings in EoE join a strong body of literature across a range of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 35197559
DOI: 10.1038/s41385-022-00486-y

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