Article
Introduction and expression of PIK3CAE545K in a papillary thyroid cancer BRAFV600E cell line leads to a dedifferentiated aggressive phenotype.
Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale - 22 Feb 2022
Pinto Nicole, Ruicci Kara M, Khan Mohammed Imran, Shaikh Mushfiq Hassan, Zeng Yu Fan Peter, Yoo John, Fung Kevin, MacNeil S Danielle, Mendez Adrian, Mymryk Joe S, Barrett John W, Boutros Paul C, Nichols Anthony C
Abstract excerpt
Anaplastic thyroid cancer (ATC) is a rare, aggressive form of undifferentiated thyroid cancer, which exhibits rapid progression and is almost universally fatal. At least a subset of ATC is thought to arise from pre-existing well-differentiated thyroid cancer, most frequently papillary thyroid cancer (PTC). While PIK3CA mutations are rare in PTC, they are common in ATC and tend to co-occur with BRAF mutations....
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