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Anaplastic Thyroid Cancers Harbor Novel Oncogenic Mutations of the <i>ALK</i> Gene

19 May 2011

Abstract excerpt

Thyroid cancer is the most common endocrine cancer, and targeted approaches to treat it pose considerable interest. In this study, we report the discovery of ALK gene mutations in thyroid cancer that may rationalize clinical evaluation of anaplastic lymphoma kinase (ALK) inhibitors in this setting. In undifferentiated anaplastic thyroid cancer (ATC), we identified two novel point mutations, C3592T and G3602A, in...

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PMID: 21596819
DOI: 10.1158/0008-5472.can-10-4041

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