Article
BRAF mutations in thyroid tumors are restricted to papillary carcinomas and anaplastic or poorly differentiated carcinomas arising from papillary carcinomas.
The Journal of clinical endocrinology and metabolism - 1 Nov 2003
Nikiforova Marina N, Kimura Edna T, Gandhi Manoj, Biddinger Paul W, Knauf Jeffrey A, Basolo Fulvio, Zhu Zhaowen, Giannini Riccardo, Salvatore Giuliana, Fusco Alfredo, Santoro Massimo, Fagin James A, Nikiforov Yuri E
Abstract excerpt
Activating point mutations of the BRAF gene have been recently reported in papillary thyroid carcinomas. In this study, we analyzed 320 thyroid tumors and six anaplastic carcinoma cell lines and detected BRAF mutations in 45 (38%) papillary carcinomas, two (13%) poorly-differentiated carcinomas, three (10%) anaplastic carcinomas, and five (83%) thyroid anaplastic carcinoma cell lines but not in follicular,...
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