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Loss of IκBζ Drives Dentin Formation via Altered H3K4me3 Status

22 Feb 2022

Abstract excerpt

Enforced enrichment of the active promoter marks trimethylation of histone H3 lysine 4 (H3K4me3) and acetylation of histone H3 lysine 27 (H3K27ac) by inhibiting histone demethylases and deacetylases is positively associated with hard tissue formation through the induction of osteo/odontogenic differentiation. However, the key endogenous epigenetic modulator of odontoblasts to regulate the expression of genes...

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PMID: 35193410
DOI: 10.1177/00220345221075968

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