Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Tooth root dentin mineralization defects in a mouse model of hypophosphatasia.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Feb 2013

Foster B L, Nagatomo K J, Tso H W, Tran A B, Nociti F H, Narisawa S, Yadav M C, McKee M D, Millán J I, Somerman M J

Abstract excerpt

Tissue-nonspecific alkaline phosphatase (TNAP) is expressed in mineralizing tissues and functions to reduce pyrophosphate (PP(i) ), a potent inhibitor of mineralization. Loss of TNAP function causes hypophosphatasia (HPP), a heritable disorder marked by increased PP(i) , resulting in rickets and osteomalacia. Tooth root cementum defects are well described in both HPP patients and in Alpl(-/-) mice, a model for...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alkaline Phosphatase
Share to Dentin

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Enzyme Replacement Therapy

Share to Gene Expression Regulation

Share to Hypophosphatasia

Share to Organogenesis

Share to Osteopontin

Share to Tooth Root

Source

Open in PubMed Open full text

Identifiers

PMID: 22991301
DOI: 10.1002/jbmr.1767
PMCID: PMC3541444

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Tooth root dentin mineralization defects in a mouse model of hypophosphatasia.PMID 22991301Read ↗

Compounded PHOSPHO1/ALPL deficiencies reduce dentin mineralization.Semantic proximity Read ↗

Dental defects in the primary dentition associated with hypophosphatasia from biallelic ALPL mutations.Semantic proximity Read ↗

Dentin sialoprotein and dentin phosphoprotein have distinct roles in dentin mineralization.Semantic proximity Read ↗

Accelerated enamel mineralization in Dspp mutant mice.Semantic proximity Read ↗

Conditional <i>Alpl</i> Ablation Phenocopies Dental Defects of HypophosphatasiaSemantic proximity Read ↗

Molecular basis of human dentin diseases.Semantic proximity Read ↗

Aberrant cementum phenotype associated with the hypophosphatemic hyp mouse.Semantic proximity Read ↗

Zebrafish enpp1 mutants exhibit pathological mineralization, mimicking features of generalized arterial calcification of infancy (GACI) and pseudoxanthoma elasticum (PXE).Semantic proximity Read ↗

DSPP Is Essential for Normal Development of the Dental-Craniofacial Complex.Semantic proximity Read ↗

Loss of skeletal mineralization by the simultaneous ablation of PHOSPHO1 and alkaline phosphatase function: a unified model of the mechanisms of initiation of skeletal calcification.Semantic proximity Read ↗

Hypercementosis Associated with ENPP1 Mutations and GACI.Semantic proximity Read ↗

Hereditary dentin defects.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.