Article
Dentin sialoprotein and dentin phosphoprotein have distinct roles in dentin mineralization.
Matrix biology : journal of the International Society for Matrix Biology - 1 May 2009
Suzuki Shigeki, Sreenath Taduru, Haruyama Naoto, Honeycutt Cherlita, Terse Anita, Cho Andrew, Kohler Thomas, Müller Ralph, Goldberg Michel, Kulkarni Ashok B
Abstract excerpt
Dentin sialophosphoprotein (DSPP), a major non-collagenous matrix protein of odontoblasts, is proteolytically cleaved into dentin sialoprotein (DSP) and dentin phosphoprotein (DPP). Our previous studies revealed that DSPP null mice display a phenotype similar to human autosomal dominant dentinogenesis imperfecta, in which teeth have widened predentin and irregular dentin mineralization resulting in sporadic...
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