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A novel nested allele-specific PCR protocol for the detection of the HLA-A*33:03, a SCAR-associated allele, in Vietnamese people.

Asian Pacific journal of allergy and immunology - 1 Dec 2024

Pham Tran Thu Ha, Tran Quang Binh, Sukasem Chonlaphat, Nguyen Van Dinh, Chu Chi Hieu, Do Thi Quynh Nga, Tran Ngoc Phuong Mai, Nguyen Hai Ha, Phung Thanh Huong

Abstract excerpt

BACKGROUND: Severe cutaneous adverse drug reactions (SCARs) are rare but deadly drug reactions with severe damages to patients. One of the most well-known SCARs risk factors is the human leukocyte antigen (HLA) genes polymorphism. Among the HLA polymorphic alleles, the HLA-A*33:03 allele has been found in association with SCARs induced by various drugs, especially in Asian people. There has not been any report on...

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PMID: 33865300
DOI: 10.12932/AP-201120-1000

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