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Article

A high-efficiency and versatile CRISPR/Cas9-mediated HDR-based biallelic editing system.

Journal of Zhejiang University. Science. B - 15 Feb 2022

Li Xinyi, Sun Bing, Qian Hongrun, Ma Jinrong, Paolino Magdalena, Zhang Zhiying

Abstract excerpt

Clustered regulatory interspaced short palindromic repeats (CRISPR)/CRISPR-associated protein 9 nuclease (Cas9), the third-generation genome editing tool, has been favored because of its high efficiency and clear system composition. In this technology, the introduced double-strand breaks (DSBs) are mainly repaired by non-homologous end joining (NHEJ) or homology-directed repair (HDR) pathways. The high-fidelity...

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Identifiers

PMID: 35187887
DOI: 10.1631/jzus.B2100196
PMCID: PMC8861562

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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