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FACS-Assisted CRISPR-Cas9 Genome Editing Facilitates Parkinson's Disease Modeling.

Stem cell reports - 14 Nov 2017

Arias-Fuenzalida Jonathan, Jarazo Javier, Qing Xiaobing, Walter Jonas, Gomez-Giro Gemma, Nickels Sarah Louise, Zaehres Holm, Schöler Hans Robert, Schwamborn Jens Christian

Abstract excerpt

Genome editing and human induced pluripotent stem cells hold great promise for the development of isogenic disease models and the correction of disease-associated mutations for isogenic tissue therapy. CRISPR-Cas9 has emerged as a versatile and simple tool for engineering human cells for such purposes. However, the current protocols to derive genome-edited lines require the screening of a great number of clones...

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Identifiers

PMID: 28988985
DOI: 10.1016/j.stemcr.2017.08.026
PMCID: PMC5830965

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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