Article
GATA2 zinc finger 1 mutations are associated with distinct clinico-biological features and outcomes different from GATA2 zinc finger 2 mutations in adult acute myeloid leukemia.
Blood cancer journal - 31 Aug 2018
Tien Feng-Ming, Hou Hsin-An, Tsai Xavier Cheng-Hong, Tang Jih-Luh, Chiu Yu-Chiao, Chen Chien-Yuan, Kuo Yuan-Yeh, Tseng Mei-Hsuan, Peng Yen-Ling, Liu Ming-Chih, Liu Chia-Wen, Liao Xiu-Wen, Lin Liang-In, Lin Chien-Ting, Wu Shang-Ju, Ko Bor-Sheng, Hsu Szu-Chun, Huang Shang-Yi, Yao Ming, Chou Wen-Chien, Tien Hwei-Fang
Abstract excerpt
Mutations of the GATA binding protein 2 (GATA2) gene in myeloid malignancies usually cluster in the zinc finger 1 (ZF1) and the ZF2 domains. Mutations in different locations of GATA2 may have distinct impact on clinico-biological features and outcomes in AML patients, but little is known in this aspect. In this study, we explored GATA2 mutations in 693 de novo non-M3 AML patients and identified 44 GATA2 mutations...
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