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A Proteomic Platform Enables to Test for AML Normalization In Vitro

1 Feb 2022

Abstract excerpt

Acute promyelocytic leukaemia (APL) can be cured by the co-administration of arsenic trioxide (ATO) and all-trans retinoic acid (ATRA). These small molecules relieve the differentiation blockade of the transformed promyelocytes and trigger their maturation into functional neutrophils, which are physiologically primed for apoptosis. This normalization therapy represents a compelling alternative to cytotoxic...

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PMID: 35178376
DOI: 10.3389/fchem.2022.826346

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