Article

Retinoic acid and proteotoxic stress induce AML cell death overcoming stromal cell protection

2023-02-21

Abstract excerpt

Acute myeloid leukemia (AML) patients bearing the ITD mutation in the tyrosine kinase receptor FLT3 (FLT3-ITD) present a poor prognosis and a high risk of relapse. FLT3-ITD is retained in the endoplasmic reticulum (ER) and generates intrinsic proteotoxic stress. We devised a strategy based on proteotoxic stress, generated by the combination of low doses of the differentiating agent retinoic acid (R), the proteasom...

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Literature Corpus work: a16ebfc7-e987-5077-a75e-5278fc258ada
DOI: 10.1101/2023.02.20.529204

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