Article
Treatment of acute promyelocytic leukaemia with <i>all-trans</i> retinoic acid and arsenic trioxide: a paradigm of synergistic molecular targeting therapy
22 Feb 2007
Abstract excerpt
To turn a disease from highly fatal to highly curable is extremely difficult, especially when the disease is a type of cancer. However, we can gain some insight into how this can be done by looking back over the 50-year history of taming acute promyelocytic leukaemia (APL). APL is the M3 type of acute myeloid leukaemia characterized by an accumulation of abnormal promyelocytes in bone marrow, a severe bleeding...
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