Article
Spatiotemporal dynamics of clonal selection and diversification in normal endometrial epithelium.
Nature communications - 17 Feb 2022
Yamaguchi Manako, Nakaoka Hirofumi, Suda Kazuaki, Yoshihara Kosuke, Ishiguro Tatsuya, Yachida Nozomi, Saito Kyota, Ueda Haruka, Sugino Kentaro, Mori Yutaro, Yamawaki Kaoru, Tamura Ryo, Revathidevi Sundaramoorthy, Motoyama Teiichi, Tainaka Kazuki, Verhaak Roel G W, Inoue Ituro, Enomoto Takayuki
Abstract excerpt
It has become evident that somatic mutations in cancer-associated genes accumulate in the normal endometrium, but spatiotemporal understanding of the evolution and expansion of mutant clones is limited. To elucidate the timing and mechanism of the clonal expansion of somatic mutations in cancer-associated genes in the normal endometrium, we sequence 1311 endometrial glands from 37 women. By collecting endometrial...
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