Article

Molecular insights into ATP synthase c-ring accumulation in BMP-deficient lysosomes in Batten disease

2026-08-06

Abstract excerpt

Bis(monoacylglycero)phosphate (BMP) is a signature lysosomal phospholipid that supports the catabolic functions of the lysosome. We recently demonstrated that BMP deficiency is associated with a variant of Batten disease, a neurodegenerative lysosomal storage disorder. This observation led us to investigate how BMP deficiency contributes to the previously reported accumulation of the ATP synthase c-ring in the lys...

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Literature Corpus work: a871b92f-4ee7-5c9e-9444-776a25040449
DOI: 10.64898/2026.08.05.743007

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