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Article

miR-486-5p expression is regulated by DNA methylation in osteosarcoma

17 Feb 2022

Abstract excerpt

BACKGROUND: Osteosarcoma is the most common primary malignant tumour of bone occurring in children and young adolescents and is characterised by complex genetic and epigenetic changes. The miRNA miR-486-5p has been shown to be downregulated in osteosarcoma and in cancer in general. RESULTS: To investigate if the mir-486 locus is epigenetically regulated, we integrated DNA methylation and miR-486-5p expression...

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PMID: 35172717
DOI: 10.1186/s12864-022-08346-6

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