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Profiling of high-grade central osteosarcoma and its putative progenitor cells identifies tumourigenic pathways

3 Nov 2009

Abstract excerpt

BACKGROUND: Osteosarcoma is the most prevalent primary malignant bone tumour in children and young adults, with poor survival in 40% of patients. To identify the signalling pathways involved in tumourigenesis, we compared gene expression in osteosarcoma with that in its presumed normal counterparts. METHODS: Genome-wide expression profiles were generated from 25 high-grade central osteosarcoma prechemotherapy...

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PMID: 19888226
DOI: 10.1038/sj.bjc.6605405

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