Hypoxia-inducible microRNA-488 regulates apoptosis by targeting Bim in osteosarcoma

Abstract excerpt

BACKGROUND: Osteosarcoma is a malignant bone cancer of which the survival rate is still low. One reason for this low survival rate is drug resistance. In the past, it has been shown that microRNAs may play critical roles in osteosarcoma development and drug resistance. The mechanisms by which osteosarcoma cells acquire this resistance have, however, remained largely unknown. Here, we aimed at assessing the role...

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