Article

miR-486 Expression is Regulated by DNA Methylation in Osteosarcoma

2020-12-03

Abstract excerpt

Osteosarcoma is the most common primary malignant tumour of bone occurring in children and young adolescents, and is characterised by complex genetic and epigenetic changes. The miRNA miR-486-5p has been shown to be downregulated in osteosarcoma and in cancer in general. To investigate if the miR-486 locus is epigenetically regulated, we integrated DNA methylation and miR-486-5p expression data using cohorts of os...

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Literature Corpus work: a99977c9-a91c-5319-b7c7-c3ff2440ab99
DOI: 10.21203/rs.3.rs-112581/v1

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